Opical imaging of biological tissue for structural characterization
Su Guvenir Torun
Su is a PhD candidate with a thesis focus on the characterization of elastic and failure properties of atherosclerotic plaques, crucial for the development of early identification tools for plaque rupture risk assessment. The tools she uses for the scope of her thesis are benchtop ex-vivo mechanical testing (inflation and tensile testing), medical imaging (MRI, ultrasound, and second harmonic generation microscopy imaging), and patient-specific computational modeling. https://www.researchgate.net/profile/Su-Guvenir-Torun
Katerina’s project is on the effect of plaque structural stress on human coronary and carotid atherosclerotic plaque progression and the impact of detailed plaque morphometric analyses over time on plaque growth. Patient-specific plaque geometries are computationally analyzed to unravel insights for plaque growth mechanisms and possible patient-specific plaque progression predictive models.
Brian is a physician-researcher and PhD candidate working for the Rotterdam Study, a large prospective, community-based, observational cohort study among 20.000 adult participants. His PhD focuses primarily on epidemiological facets of stroke, transient ischemic attack, and recurrent stroke. Next to these clinical outcomes he also works on biomechanical subjects relating to arteriosclerosis and how aspects such as common carotid shear stress and geometry of intracranial arteries affect stroke risk. https://orcid.org/0000-0002-5101-0132
Hanneke is dissecting atherosclerotic cap composition in relation to mechanical properties and cap failure mode. She makes use of tissue-engineered constructs to mimic the composition and mechanical behavior of human caps. Specifically, she focuses on the role of (local) strain in atherosclerotic cap rupture.
Federica’s research project focuses on the computational modeling of intracranial vascular calcification, with the aim to unravel the biomechanical mechanisms involved in calcium deposition and their link to clinical events such as stroke and cognitive function impairment. To address this question, she uses a combination of various modeling and image-processing techniques, among which Fluid-Structure Interaction simulations.
Structural and mechanical characerization of vascular tissue in health and disease
Sanne van Kuijk
Computational modeling of carotid circulation for understanding the link to degenerative cerebrovascular diseases